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Target
NAD-dependent protein deacetylase
Ligand
BDBM50156760
Substrate
n/a
Meas. Tech.
ChEMBL_936768 (CHEMBL2320160)
IC50
193800±n/a nM
Citation
 Zheng, W Sirtuins as emerging anti-parasitic targets. Eur J Med Chem 59:132-40 (2013) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase
Synonyms:
Putative silent information regulator 2 | SIR2-like protein | SIR2RP1
Type:
PROTEIN
Mol. Mass.:
40532.98
Organism:
Leishmania infantum
Description:
ChEMBL_936768
Residue:
373
Sequence:
MTASPRAPHQEHVLGEPTLEGLAHYIREKNVRRILVLVGAGASVAAGIPDFRSPDTGIYANLGKYNLEDPTDAFSLTLLREKPEIFYSIARELNLWPGHFQPTAVHHFIRLLQDEGRLLRCCTQNIDGLEKAAGVSPELLVEAHGSFAAAACIECHTPFSIEQNYLEAMSGTVSRCSTCGGIVKPNVVFFGENLPDAFFDALHHDAPIAELVIIIGTSMQVHPFALLPCVVPKSVPRVVMNRERVGGLLFRFPDDPLNTVHEDAVAKEGRSSSSQSRSPSASPRREEGGTEDSPSSPNEEVEEASTSSSSDGYGQYGDYHAHPDVCRDVLFRGDCQENVVTLAEYLGLSEALAKRMRLSDAAPATAQRAPNET
  
Inhibitor
Name:
BDBM50156760
Synonyms:
(E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N-(1-phenylethyl)benzamide | 2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N-(1-phenylethyl)benzamide | 2-{[(1-(2-hydroxy-naphthalen-1-yl)meth-(E)-ylidene]amino}-N-(1-phenylethyl)-benzamide | 2-{[1-(2-hydroxynaphthalen-1-yl)meth-(E)-ylene]amino}-N-(1-phenylethyl)benzamide | CHEMBL380797 | Sirtinol
Type:
Small organic molecule
Emp. Form.:
C26H22N2O2
Mol. Mass.:
394.4651
SMILES:
CC(NC(=O)c1ccccc1\N=C\c1c(O)ccc2ccccc12)c1ccccc1
Structure:
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