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Target
DNA repair protein RAD51 homolog 1
Ligand
BDBM50424496
Substrate
n/a
Meas. Tech.
ChEMBL_937387 (CHEMBL2319671)
IC50
250±n/a nM
Citation
 Budke, B; Kalin, JH; Pawlowski, M; Zelivianskaia, AS; Wu, M; Kozikowski, AP; Connell, PP An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity. J Med Chem 56:254-63 (2013) [PubMed]  Article 
Target
Name:
DNA repair protein RAD51 homolog 1
Synonyms:
RAD51 | RAD51A | RAD51_HUMAN | RECA
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36960.74
Organism:
Homo sapiens (Human)
Description:
gi_49168602
Residue:
339
Sequence:
MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGFHTVEAVAYAPKKELINIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGLSGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD
  
Inhibitor
Name:
BDBM50424496
Synonyms:
CHEMBL2316725
Type:
Small organic molecule
Emp. Form.:
C14H11Cl2IN2O3
Mol. Mass.:
453.059
SMILES:
Clc1ccc(cc1Cl)N1C(=O)C(I)=C(N2CCOCC2)C1=O |t:13|
Structure:
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