Target
Leukotriene A-4 hydrolase
Ligand
BDBM50425170
Substrate
n/a
Meas. Tech.
ChEMBL_936844 (CHEMBL2320478)
IC50
3.7±n/a nM
Citation
 Eccles, WBlevitt, JMBooker, JNChrovian, CCCrawford, Sde Leon, ARDeng, XFourie, AMGrice, CAHerman, KKarlsson, LKearney, AMLee-Dutra, ALiang, JLuna, RPippel, DRao, NRiley, JPSantillán, ASavall, BTanis, VMXue, XYoung, AL Identification of benzofuran central cores for the inhibition of leukotriene A(4) hydrolase. Bioorg Med Chem Lett 23:811-5 (2013) [PubMed]  Article 
Target
Name:
Leukotriene A-4 hydrolase
Synonyms:
LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase
Type:
Hydrolase; metalloprotease
Mol. Mass.:
69280.41
Organism:
Homo sapiens (Human)
Description:
Human recombinant LTA4H.
Residue:
611
Sequence:
MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD
  
Inhibitor
Name:
BDBM50425170
Synonyms:
CHEMBL2313569
Type:
Small organic molecule
Emp. Form.:
C22H22N4O3S
Mol. Mass.:
422.5
SMILES:
CC(=O)NC1CCN(Cc2coc3cc(Oc4nc5ncccc5s4)ccc23)CC1
Structure:
Search PDB for entries with ligand similarity: