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Target
Baculoviral IAP repeat-containing protein 3
Ligand
BDBM50425723
Substrate
n/a
Meas. Tech.
ChEMBL_937825 (CHEMBL2318322)
IC50
3.4±n/a nM
Citation
 Hashimoto, K; Saito, B; Miyamoto, N; Oguro, Y; Tomita, D; Shiokawa, Z; Asano, M; Kakei, H; Taya, N; Kawasaki, M; Sumi, H; Yabuki, M; Iwai, K; Yoshida, S; Yoshimatsu, M; Aoyama, K; Kosugi, Y; Kojima, T; Morishita, N; Dougan, DR; Snell, GP; Imamura, S; Ishikawa, T Design and synthesis of potent inhibitor of apoptosis (IAP) proteins antagonists bearing an octahydropyrrolo[1,2-a]pyrazine scaffold as a novel proline mimetic. J Med Chem 56:1228-46 (2013) [PubMed]  Article 
Target
Name:
Baculoviral IAP repeat-containing protein 3
Synonyms:
API2 | BIRC3 | BIRC3_HUMAN | Baculoviral IAP repeat-containing protein 3 | Baculoviral IAP repeat-containing protein 3 (IAP1 BIR3) | Inhibitor of apoptosis protein 3 (cIAP2) | MIHC | RNF49 | XIAP-BIR3 | cIAP1/cIAP2
Type:
Protein
Mol. Mass.:
68365.75
Organism:
Homo sapiens (Human)
Description:
Q13489
Residue:
604
Sequence:
MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS
  
Inhibitor
Name:
BDBM50425723
Synonyms:
CHEMBL2316214
Type:
Small organic molecule
Emp. Form.:
C28H41N5O5
Mol. Mass.:
527.6556
SMILES:
CN[C@@H](C)C(=O)N[C@@H](C1CCOCC1)C(=O)N1C[C@H]2CCCN2C[C@H]1C(=O)N[C@@H]1CCOc2ccccc12 |r|
Structure:
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