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TargetKynurenine--oxoglutarate transaminase 3
LigandBDBM50386292
Substrate/Competitorn/a
Meas. Tech.ChEMBL_939752
IC50 9040±n/a nM
Citation Tuttle, JBAnderson, MBechle, BMCampbell, BMChang, CDounay, ABEvrard, EFonseca, KRGan, XGhosh, SHorner, WJames, LCKim, JYMcAllister, LAPandit, JParikh, VDRago, BJSalafia, MAStrick, CAZawadzke, LEVerhoest, PR Structure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing Interactions. ACS Med Chem Lett4:37-40 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Kynurenine--oxoglutarate transaminase 3
Name:Kynurenine--oxoglutarate transaminase 3
Synonyms:CCBL2 | Cysteine-S-conjugate beta-lyase 2 | KAT3 | KATIII | Kynurenine aminotransferase III | Kynurenine--glyoxylate transaminase | Kynurenine--oxoglutarate transaminase III
Type:PROTEIN
Mol. Mass.:51406.81
Organism:Homo sapiens (Human)
Description:ChEMBL_939752
Residue:454
Sequence:
MFLAQRSLCSLSGRAKFLKTISSSKILGFSTSAKMSLKFTNAKRIEGLDSNVWIEFTKLA
ADPSVVNLGQGFPDISPPTYVKEELSKIAAIDSLNQYTRGFGHPSLVKALSYLYEKLYQK
QIDSNKEILVTVGAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRS
KPVYGKRWSSSDWTLDPQELESKFNSKTKAIILNTPHNPLGKVYNREELQVIADLCIKYD
TLCISDEVYEWLVYSGNKHLKIATFPGMWERTITIGSAGKTFSVTGWKLGWSIGPNHLIK
HLQTVQQNTIYTCATPLQEALAQAFWIDIKRMDDPECYFNSLPKELEVKRDRMVRLLESV
GLKPIVPDGGYFIIADVSLLDPDLSDMKNNEPYDYKFVKWMTKHKKLSAIPVSAFCNSET
KSQFEKFVRFCFIKKDSTLDAAEEIIKAWSVQKS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50386292
NameBDBM50386292
Synonyms:CHEMBL2047851
TypeSmall organic molecule
Emp. Form.C9H10N2O2
Mol. Mass.178.1879
SMILESN[C@H]1Cc2ccccc2N(O)C1=O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a