Target
Kynurenine--oxoglutarate transaminase 1
Ligand
BDBM50386310
Substrate
n/a
Meas. Tech.
ChEMBL_939755 (CHEMBL2329108)
IC50
15300±n/a nM
Citation
 Tuttle, JBAnderson, MBechle, BMCampbell, BMChang, CDounay, ABEvrard, EFonseca, KRGan, XGhosh, SHorner, WJames, LCKim, JYMcAllister, LAPandit, JParikh, VDRago, BJSalafia, MAStrick, CAZawadzke, LEVerhoest, PR Structure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing Interactions. ACS Med Chem Lett 4:37-40 (2013) [PubMed]  Article 
Target
Name:
Kynurenine--oxoglutarate transaminase 1
Synonyms:
CCBL1 | Cysteine-S-conjugate beta-lyase | Glutamine--phenylpyruvate transaminase | KAT1_HUMAN | KYAT1 | Kynurenine Aminotransferase 1/Glutamine Transaminase K | Kynurenine--oxoglutarate transaminase 1
Type:
Aminotransferase; Lyase
Mol. Mass.:
47874.00
Organism:
Homo sapiens (Human)
Description:
Recombinant hKAT-1 was expressed and purified from Sf9 insect cells.
Residue:
422
Sequence:
MAKQLQARRLDGIDYNPWVEFVKLASEHDVVNLGQGFPDFPPPDFAVEAFQHAVSGDFMLNQYTKTFGYPPLTKILASFFGELLGQEIDPLRNVLVTVGGYGALFTAFQALVDEGDEVIIIEPFFDCYEPMTMMAGGRPVFVSLKPGPIQNGELGSSSNWQLDPMELAGKFTSRTKALVLNTPNNPLGKVFSREELELVASLCQQHDVVCITDEVYQWMVYDGHQHISIASLPGMWERTLTIGSAGKTFSATGWKVGWVLGPDHIMKHLRTVHQNSVFHCPTQSQAAVAESFEREQLLFRQPSSYFVQFPQAMQRCRDHMIRSLQSVGLKPIIPQGSYFLITDISDFKRKMPDLPGAVDEPYDRRFVKWMIKNKGLVAIPVSIFYSVPHQKHFDHYIRFCFVKDEATLQAMDEKLRKWKVEL
  
Inhibitor
Name:
BDBM50386310
Synonyms:
CHEMBL2049092
Type:
Small organic molecule
Emp. Form.:
C10H12N2O3
Mol. Mass.:
208.2139
SMILES:
COc1ccc2C[C@H](N)C(=O)N(O)c2c1 |r|
Structure:
Search PDB for entries with ligand similarity: