Target
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Ligand
BDBM50386310
Substrate
n/a
Meas. Tech.
ChEMBL_939756 (CHEMBL2329109)
Ki
7.7±n/a nM
Citation
 Tuttle, JBAnderson, MBechle, BMCampbell, BMChang, CDounay, ABEvrard, EFonseca, KRGan, XGhosh, SHorner, WJames, LCKim, JYMcAllister, LAPandit, JParikh, VDRago, BJSalafia, MAStrick, CAZawadzke, LEVerhoest, PR Structure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing Interactions. ACS Med Chem Lett 4:37-40 (2013) [PubMed]  Article 
Target
Name:
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Synonyms:
2-aminoadipate aminotransferase | 2-aminoadipate transaminase | AADAT | AADAT_HUMAN | Alpha-aminoadipate aminotransferase | KAT/AadAT | KAT2 | KYAT2 | Kynurenine aminotransferase II | Kynurenine aminotransferase II (KAT II) | Kynurenine--oxoglutarate aminotransferase II | Kynurenine--oxoglutarate transaminase 2 | Kynurenine--oxoglutarate transaminase II
Type:
Enzyme
Mol. Mass.:
47353.09
Organism:
Homo sapiens (Human)
Description:
Q8N5Z0
Residue:
425
Sequence:
MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLIKESL
  
Inhibitor
Name:
BDBM50386310
Synonyms:
CHEMBL2049092
Type:
Small organic molecule
Emp. Form.:
C10H12N2O3
Mol. Mass.:
208.2139
SMILES:
COc1ccc2C[C@H](N)C(=O)N(O)c2c1 |r|
Structure:
Search PDB for entries with ligand similarity: