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Target
Apoptosis regulator Bcl-2
Ligand
BDBM50426412
Substrate
n/a
Meas. Tech.
ChEMBL_940158 (CHEMBL2328333)
Kd
10.0±n/a nM
Citation
 Touré, BB; Miller-Moslin, K; Yusuff, N; Perez, L; Doré, M; Joud, C; Michael, W; DiPietro, L; van der Plas, S; McEwan, M; Lenoir, F; Hoe, M; Karki, R; Springer, C; Sullivan, J; Levine, K; Fiorilla, C; Xie, X; Kulathila, R; Herlihy, K; Porter, D; Visser, M The role of the acidity of N-heteroaryl sulfonamides as inhibitors of bcl-2 family protein-protein interactions. ACS Med Chem Lett 4:186-90 (2013) [PubMed]  Article 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50426412
Synonyms:
CHEMBL2322022
Type:
Small organic molecule
Emp. Form.:
C45H48ClF6N7O4S3
Mol. Mass.:
996.546
SMILES:
CN(C)CC[C@H](CSc1ccccc1)Nc1ccc(cc1S(=O)(=O)C(F)(F)F)S(=O)(=O)Nc1nc(nc2CN(CCc12)C1CCN(Cc2ccccc2-c2ccc(Cl)cc2)CC1)C(F)(F)F |r|
Structure:
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