Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 3A
Ligand
BDBM50426730
Substrate
n/a
Meas. Tech.
ChEMBL_940560 (CHEMBL2327178)
Kd
83±n/a nM
Citation
 Silva-Lopez, EI; Barden, AO; Brozik, JA Near native binding of a fluorescent serotonin conjugate to serotonin type 3 receptors. Bioorg Med Chem Lett 23:773-5 (2013) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 3A
Synonyms:
5-HT-3 | 5-HT3 | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 (5-HT3) | 5-hydroxytryptamine receptor 3A (5-HT3a) | 5-hydroxytryptamine receptor 3A (5HT3A) | 5HT3A_HUMAN | 5HT3R | HTR3 | HTR3A | Serotonin 3 (5-HT3) receptor | Serotonin 3 receptor (5HT3) | Serotonin receptor 3A | Serotonin-gated ion channel receptor | Serotonin-gated ion channel receptor 3
Type:
Protein
Mol. Mass.:
55283.27
Organism:
Homo sapiens (Human)
Description:
P46098
Residue:
478
Sequence:
MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
  
Inhibitor
Name:
BDBM50426730
Synonyms:
CHEMBL2322133
Type:
Small organic molecule
Emp. Form.:
C43H48N6O6
Mol. Mass.:
744.8778
SMILES:
CN(C)c1ccc2c(-c3ccc(cc3C([O-])=O)C(=O)NCCCCCNC(=O)CCn3cc(CCN)c4cc(O)ccc34)c3ccc(cc3oc2c1)=[N+](C)C |(34.43,-4.19,;33.09,-3.43,;33.08,-1.89,;31.76,-4.21,;30.41,-3.47,;29.09,-4.27,;29.11,-5.81,;27.78,-6.61,;26.43,-5.86,;26.42,-4.32,;25.07,-3.58,;23.76,-4.37,;23.78,-5.92,;25.12,-6.66,;25.15,-8.2,;23.84,-8.99,;25.91,-9.52,;22.41,-3.63,;22.38,-2.09,;21.09,-4.42,;19.74,-3.68,;18.42,-4.48,;17.07,-3.73,;15.76,-4.53,;14.41,-3.78,;13.09,-4.58,;11.74,-3.83,;11.71,-2.29,;10.42,-4.63,;9.07,-3.88,;7.75,-4.68,;6.49,-3.8,;5.27,-4.73,;3.79,-4.3,;3.43,-2.8,;1.95,-2.37,;5.79,-6.18,;5.05,-7.53,;5.85,-8.84,;5.12,-10.19,;7.39,-8.8,;8.12,-7.45,;7.32,-6.15,;27.82,-8.15,;26.49,-8.95,;26.53,-10.49,;27.89,-11.24,;29.21,-10.45,;29.18,-8.89,;30.5,-8.1,;30.47,-6.57,;31.78,-5.76,;27.93,-12.78,;26.62,-13.59,;29.29,-13.51,)|
Structure:
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