Reaction Details Report a problem with these data
Target
Farnesyl diphosphate synthase
Ligand
BDBM12576
Substrate
n/a
Meas. Tech.
ChEMBL_939177 (CHEMBL2329369)
IC50
27±n/a nM
Citation
Recher, M; Barboza, AP; Li, ZH; Galizzi, M; Ferrer-Casal, M; Szajnman, SH; Docampo, R; Moreno, SN; Rodriguez, JB Design, synthesis and biological evaluation of sulfur-containing 1,1-bisphosphonic acids as antiparasitic agents. Eur J Med Chem 60:431-40 (2013) [PubMed] Article
More Info.:
Target
Name:
Farnesyl diphosphate synthase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
48827.21
Organism:
Trypanosoma cruzi
Description:
ChEMBL_939177
Residue:
425
Sequence:
MTAFACFPHSLFYSTRLPFFFFFFCVCVHCCLRYLCLLKCAYCCSDKNYFRPLNYFFYCLYLAMASMERFLSVYDEVQAFLLDQLQSKYEIDPNRARYLRIMMDTTCLGGKYFRGMTVVNVAEGFLAVTQHDEATKERILHDACVGGWMIEFLQAHYLVEDDIMDGSVMRRGKPCWYRFPGVTTQCAINDGIILKSWTQIMAWHYFADRPFLKDLLCLFQKVDYATAVGQMYDVTSMCDSNKLDPEVAQPMTTDFAEFTPAIYKRIVKYKTTFYTYLLPLVMGLLVSEAAASVEMNLVERVAHLIGEYFQVQDDVMDCFTPPEQLGKVGTDIEDAKCSWLAVTFLGKANAAQVAEFKANYGEKDPAKVAVVKRLYSKANLQADFAAYEAEVVREVESLIEQLKVKSPTFAESVAVVWEKTHKRKK
Inhibitor
Name:
BDBM12576
Synonyms:
Bisphosphonate 1 | CHEMBL923 | JMC515594 Compound 64 | RIS | Risdronate | US11279719, Example Risedronic acid RIS | [1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethyl]phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C7H11NO7P2
Mol. Mass.:
283.1123
SMILES:
OC(Cc1cccnc1)(P(O)(O)=O)P(O)(O)=O