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Target
Proteasome subunit beta type-2
Ligand
BDBM50427001
Substrate
n/a
Meas. Tech.
ChEMBL_939308 (CHEMBL2327273)
IC50
190±n/a nM
Citation
 Geurink, PP; van der Linden, WA; Mirabella, AC; Gallastegui, N; de Bruin, G; Blom, AE; Voges, MJ; Mock, ED; Florea, BI; van der Marel, GA; Driessen, C; van der Stelt, M; Groll, M; Overkleeft, HS; Kisselev, AF Incorporation of non-natural amino acids improves cell permeability and potency of specific inhibitors of proteasome trypsin-like sites. J Med Chem 56:1262-75 (2013) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-2
Synonyms:
20S proteasome | PSB2_HUMAN | PSMB2 | Proteasome Macropain subunit
Type:
PROTEIN
Mol. Mass.:
22837.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1294233
Residue:
201
Sequence:
MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYIQKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSVRIIDKNGIHDLDNISFPKQGS
  
Inhibitor
Name:
BDBM50427001
Synonyms:
CHEMBL2326264
Type:
Small organic molecule
Emp. Form.:
C33H47N7O5S
Mol. Mass.:
653.835
SMILES:
CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(CN)cc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])\C=C\S(C)(=O)=O |r|
Structure:
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