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Target
Carbonic anhydrase 1
Ligand
BDBM4703
Substrate
n/a
Meas. Tech.
ChEMBL_938521 (CHEMBL2327205)
Ki
164±n/a nM
Citation
 Pan, P; Vermelho, AB; Capaci Rodrigues, G; Scozzafava, A; Tolvanen, ME; Parkkila, S; Capasso, C; Supuran, CT Cloning, characterization, and sulfonamide and thiol inhibition studies of ana-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease. J Med Chem 56:1761-71 (2013) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 1
Synonyms:
CA-I | CA1 | CAB | CAH1_HUMAN | Carbonate dehydratase I | Carbonic anhydrase | Carbonic anhydrase 1 (CA I) | Carbonic anhydrase 1 (CA-I) | Carbonic anhydrase 1 (Recombinant CA I) | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase B | Carbonic anhydrase I | Carbonic anhydrase I (CA I) | Carbonic anhydrase I (CA-I) | Carbonic anhydrase I (CAI) | Carbonic anhydrase I (hCA I) | Carbonic anhydrase isoenzyme I (hCA I) | hCA
Type:
Enzyme
Mol. Mass.:
28873.37
Organism:
Homo sapiens (Human)
Description:
P00915
Residue:
261
Sequence:
MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF
  
Inhibitor
Name:
BDBM4703
Synonyms:
4-carboxybenzenesulfonamide 1 | 4-sulfamoylbenzoic acid | Benzoic Acid deriv. 31 | CHEMBL414 | JMC522226 Compound 22 | JMC523116 Compound 22 | JMC52646 Compound 23 | aromatic/heteroaromatic sulfonamide 23
Type:
Small organic molecule
Emp. Form.:
C7H7NO4S
Mol. Mass.:
201.2
SMILES:
NS(=O)(=O)c1ccc(cc1)C(O)=O
Structure:
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