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Target
Insulin-degrading enzyme
Ligand
BDBM50427711
Substrate
n/a
Meas. Tech.
ChEMBL_941899 (CHEMBL2329965)
Ki
18000±n/a nM
Citation
 Abdul-Hay, SO; Lane, AL; Caulfield, TR; Claussin, C; Bertrand, J; Masson, A; Choudhry, S; Fauq, AH; Maharvi, GM; Leissring, MA Optimization of peptide hydroxamate inhibitors of insulin-degrading enzyme reveals marked substrate-selectivity. J Med Chem 56:2246-55 (2013) [PubMed]  Article 
Target
Name:
Insulin-degrading enzyme
Synonyms:
Abeta-degrading protease | Human Insulin Degrading Enzyme (hIDE) | IDE | IDE_HUMAN | Insulin degrading enzyme (hIDE) | Insulin protease | Insulin-degrading enzyme | Insulinase | Insulysin | insulin-degrading enzyme isoform 1 precursor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
117968.59
Organism:
Homo sapiens (Human)
Description:
P14735
Residue:
1019
Sequence:
MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
  
Inhibitor
Name:
BDBM50427711
Synonyms:
CHEMBL2324211
Type:
Small organic molecule
Emp. Form.:
C32H38N8O6
Mol. Mass.:
630.6941
SMILES:
NC(N)=NCCC[C@H](NC(=O)[C@H](Cc1ccc2ccccc2c1)[C@H](O)C(=O)NO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O |r,wU:7.7,11.10,wD:32.33,23.25,(34.92,-22.98,;36.29,-23.69,;37.59,-22.86,;36.35,-25.23,;35.06,-26.05,;35.13,-27.59,;33.83,-28.42,;33.9,-29.96,;32.6,-30.79,;31.28,-30.02,;31.28,-28.48,;29.94,-30.79,;28.63,-30.02,;28.6,-28.48,;27.25,-27.73,;27.22,-26.19,;28.54,-25.39,;28.5,-23.85,;29.82,-23.06,;31.18,-23.79,;31.22,-25.33,;29.89,-26.14,;29.92,-27.68,;29.94,-32.33,;31.27,-33.1,;28.6,-33.1,;27.27,-32.33,;28.6,-34.64,;27.27,-35.42,;35.26,-30.66,;35.33,-32.2,;36.56,-29.84,;37.93,-30.55,;38,-32.09,;39.36,-32.79,;40.81,-32.29,;41.74,-33.52,;40.86,-34.78,;41.21,-36.28,;40.09,-37.33,;38.62,-36.88,;38.27,-35.38,;39.39,-34.33,;39.23,-29.72,;40.59,-30.43,;39.15,-28.18,)|
Structure:
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