Target
Protein arginine N-methyltransferase 3 [N508S]
Ligand
BDBM50427789
Substrate
n/a
Meas. Tech.
ChEMBL_941988 (CHEMBL2330282)
IC50
840±n/a nM
Citation
 Liu, FLi, FMa, ADobrovetsky, EDong, AGao, CKorboukh, ILiu, JSmil, DBrown, PJFrye, SVArrowsmith, CHSchapira, MVedadi, MJin, J Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors. J Med Chem 56:2110-24 (2013) [PubMed]  Article 
Target
Name:
Protein arginine N-methyltransferase 3 [N508S]
Synonyms:
ANM3_HUMAN | HRMT1L3 | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3 | PRMT3 | Protein arginine N-methyltransferase 3 | Protein arginine N-methyltransferase 3 (PRMT3)
Type:
Protein
Mol. Mass.:
59859.85
Organism:
Homo sapiens (Human)
Description:
O60678[N508S]
Residue:
531
Sequence:
MCSLASGATGGRGAVENEEDLPELSDSGDEAAWEDEDDADLPHGKQQTPCLFCNRLFTSAEETFSHCKSEHQFNIDSMVHKHGLEFYGYIKLINFIRLKNPTVEYMNSIYNPVPWEKEEYLKPVLEDDLLLQFDVEDLYEPVSVPFSYPNGLSENTSVVEKLKHMEARALSAEAALARAREDLQKMKQFAQDFVMHTDVRTCSSSTSVIADLQEDEDGVYFSSYGHYGIHEEMLKDKIRTESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQAMDIIRLNKLEDTITLIKGKIEEVHLPVEKVDVIISEWMGYFLLFESMLDSVLYAKNKYLAKGGSVYPDICTISLVAVSDVNKHADRIAFWDDVYGFKMSCMKKAVIPEAVVEVLDPKTLISEPCGIKHIDCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNCHNRVVFSTGPQSTKTHWKQTVFLLEKPFSVKAGEALKGKVTVHKSKKDPRSLTVTLTLNNSTQTYGLQ
  
Inhibitor
Name:
BDBM50427789
Synonyms:
CHEMBL2325196
Type:
Small organic molecule
Emp. Form.:
C15H18N4O2S
Mol. Mass.:
318.394
SMILES:
O=C(NCC(=O)C1CCCCC1)Nc1ccc2nnsc2c1
Structure:
Search PDB for entries with ligand similarity: