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Target
Hypoxanthine-guanine phosphoribosyltransferase
Ligand
BDBM50427810
Substrate
n/a
Meas. Tech.
ChEMBL_940694 (CHEMBL2329985)
Ki
30±n/a nM
Citation
 Keough, DT; Špacek, P; Hocková, D; Tichý, T; Vrbková, S; Slavetínská, L; Janeba, Z; Naesens, L; Edstein, MD; Chavchich, M; Wang, TH; de Jersey, J; Guddat, LW Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity. J Med Chem 56:2513-26 (2013) [PubMed]  Article 
Target
Name:
Hypoxanthine-guanine phosphoribosyltransferase
Synonyms:
HGPRT | HGPRTase | HPRT | HPRT1 | HPRT_HUMAN | Hypoxanthine-guanine phosphoribosyltransferase | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)
Type:
Protein
Mol. Mass.:
24579.61
Organism:
Homo sapiens (Human)
Description:
P00492
Residue:
218
Sequence:
MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
  
Inhibitor
Name:
BDBM50427810
Synonyms:
CHEMBL2325752
Type:
Small organic molecule
Emp. Form.:
C11H19N5O9P2
Mol. Mass.:
427.2442
SMILES:
Nc1nc2n(CC(COCP(O)(O)=O)COCP(O)(O)=O)cnc2c(=O)[nH]1
Structure:
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