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TargetApoptosis regulator Bcl-2
LigandBDBM50393832
Substrate/Competitorn/a
Meas. Tech.ChEMBL_940709
IC50 2.0±n/a nM
Citation Aguilar, AZhou, HChen, JLiu, LBai, LMcEachern, DYang, CYMeagher, JStuckey, JWang, S A potent and highly efficacious Bcl-2/Bcl-xL inhibitor. J Med Chem56:3048-67 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Apoptosis regulator Bcl-2
Name:Apoptosis regulator Bcl-2
Synonyms:Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | Bcl-2 Protein
Type:Homodimer or heterodimer
Mol. Mass.:26269.11
Organism:Homo sapiens (Human)
Description:P10415
Residue:239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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  Blast E-value cutoff:
BDBM50393832
NameBDBM50393832
Synonyms:CHEMBL2159739
TypeSmall organic molecule
Emp. Form.C48H52ClN7O6S2
Mol. Mass.922.553
SMILESCCn1c(C)c(C(O)=O)c(c1-c1ccc(Cl)cc1)-c1cccc(c1)N1CCN(CC1)c1ccc(NS(=O)(=O)c2ccc(N[C@H](CCN(C)C)CSc3ccccc3)c(c2)[N+]([O-])=O)cc1 |r|
Structure
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