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TargetEphrin receptor
LigandBDBM50428059
Substrate/Competitorn/a
Meas. Tech.ChEMBL_941275
IC50 5800±n/a nM
Citation Incerti, MTognolini, MRusso, SPala, DGiorgio, CHassan-Mohamed, INoberini, RPasquale, EBVicini, PPiersanti, SRivara, SBarocelli, EMor, MLodola, A Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. J Med Chem56:2936-47 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Ephrin receptor
Name:Ephrin type-B receptor 6
Synonyms:Ephrin type-B receptor 6 | HEP | Tyrosine-protein kinase-defective receptor EPH-6
Type:PROTEIN
Mol. Mass.:110701.54
Organism:Homo sapiens (Human)
Description:ChEMBL_774437
Residue:1021
Sequence:
MATEGAAQLGNRVAGMVCSLWVLLLVSSVLALEEVLLDTTGETSEIGWLTYPPGGWDEVS
VLDDQRRLTRTFEACHVAGAPPGTGQDNWLQTHFVERRGAQRAHIRLHFSVRACSSLGVS
GGTCRETFTLYYRQAEEPDSPDSVSSWHLKRWTKVDTIAADESFPSSSSSSSSSSSAAWA
VGPHGAGQRAGLQLNVKERSFGPLTQRGFYVAFQDTGACLALVAVRLFSYTCPAVLRSFA
SFPETQASGAGGASLVAAVGTCVAHAEPEEDGVGGQAGGSPPRLHCNGEGKWMVAVGGCR
CQPGYQPARGDKACQACPRGLYKSSAGNAPCSPCPARSHAPNPAAPVCPCLEGFYRASSD
PPEAPCTGPPSAPQELWFEVQGSALMLHWRLPRELGGRGDLLFNVVCKECEGRQEPASGG
GGTCHRCRDEVHFDPRQRGLTESRVLVGGLRAHVPYILEVQAVNGVSELSPDPPQAAAIN
VSTSHEVPSAVPVVHQVSRASNSITVSWPQPDQTNGNILDYQLRYYDQAEDESHSFTLTS
ETNTATVTQLSPGHIYGFQVRARTAAGHGPYGGKVYFQTLPQGELSSQLPERLSLVIGSI
LGALAFLLLAAITVLAVVFQRKRRGTGYTEQLQQYSSPGLGVKYYIDPSTYEDPCQAIRE
LAREVDPAYIKIEEVIGTGSFGEVRQGRLQPRGRREQTVAIQALWAGGAESLQMTFLGRA
AVLGQFQHPNILRLEGVVTKSRPLMVLTEFMELGPLDSFLRQREGQFSSLQLVAMQRGVA
AAMQYLSSFAFVHRSLSAHSVLVNSHLVCKVARLGHSPQGPSCLLRWAAPEVIAHGKHTT
SSDVWSFGILMWEVMSYGERPYWDMSEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQK
DRARRPHFDQLVAAFDKMIRKPDTLQAGGDPGERPSQALLTPVALDFPCLDSPQAWLSAI
GLECYQDNFSKFGLCTFSDVAQLSLEDLPALGITLAGHQKKLLHHIQLLQQHLRQQGSVE
V
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  Blast E-value cutoff:
BDBM50428059
NameBDBM50428059
Synonyms:CHEMBL2322989
TypeSmall organic molecule
Emp. Form.C35H50N2O4
Mol. Mass.562.7825
SMILESC[C@H](CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a