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Target
Beta-secretase 2
Ligand
BDBM50428341
Substrate
n/a
Meas. Tech.
ChEMBL_947398 (CHEMBL2345047)
IC50
5±n/a nM
Citation
 Blass, B Cyclopropyl-Fused 1,3-Thiazepines as BACE1 and BACE2 Inhibitors. ACS Med Chem Lett 4:379-80 (2013) [PubMed]  Article 
Target
Name:
Beta-secretase 2
Synonyms:
BACE2_RAT | Bace2 | Beta-site APP cleaving enzyme 2 | Beta-site amyloid precursor protein cleaving enzyme 2 | Memapsin-1 | Membrane-associated aspartic protease 1 | Theta-secretase
Type:
PROTEIN
Mol. Mass.:
55848.42
Organism:
Rattus norvegicus
Description:
ChEMBL_1351639
Residue:
514
Sequence:
MGALLRALLLPLLAQWLLRAVPVLAPAPFTLPLQVAGAANHRASTVPGLGTPELPRADGLALALEPARATANFLAMVDNLQGDSGRGYYLEMLIGTPPQKVRILVDTGSSNFAVAGAPHSYIDTYFDSESSSTYHSKGFEVTVKYTQGSWTGFVGEDLVTIPKGFNSSFLVNIATIFESENFFLPGIKWNGILGLAYAALAKPSSSLETFFDSLVAQAKIPDIFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARTSLIPEFSDGFWTGAQLACWTNSETPWAYFPKISIYLRDENASRSFRITILPQLYIQPMMGAGFNYECYRFGISSSTNALVIGATVMEGFYVVFDRAQRRVGFAVSPCAEIAGTTVSEISGPFSTEDIASNCVPAQALNEPILWIVSYALMSVCGAILLVLILLLLFPLHCRHAPRDPEVVNDESSLVRHRWK
  
Inhibitor
Name:
BDBM50428341
Synonyms:
CHEMBL2331713
Type:
Small organic molecule
Emp. Form.:
C19H16FN5OS
Mol. Mass.:
381.427
SMILES:
NC1=N[C@]2(C[C@H]2CCS1)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F |r,t:1|
Structure:
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