Target
Beta-secretase 2
Ligand
BDBM50428342
Substrate
n/a
Meas. Tech.
ChEMBL_947398 (CHEMBL2345047)
IC50
2.0±n/a nM
Citation
 Blass, B Cyclopropyl-Fused 1,3-Thiazepines as BACE1 and BACE2 Inhibitors. ACS Med Chem Lett 4:379-80 (2013) [PubMed]  Article 
Target
Name:
Beta-secretase 2
Synonyms:
BACE2_RAT | Bace2 | Beta-site APP cleaving enzyme 2 | Beta-site amyloid precursor protein cleaving enzyme 2 | Memapsin-1 | Membrane-associated aspartic protease 1 | Theta-secretase
Type:
PROTEIN
Mol. Mass.:
55848.42
Organism:
Rattus norvegicus
Description:
ChEMBL_1351639
Residue:
514
Sequence:
MGALLRALLLPLLAQWLLRAVPVLAPAPFTLPLQVAGAANHRASTVPGLGTPELPRADGLALALEPARATANFLAMVDNLQGDSGRGYYLEMLIGTPPQKVRILVDTGSSNFAVAGAPHSYIDTYFDSESSSTYHSKGFEVTVKYTQGSWTGFVGEDLVTIPKGFNSSFLVNIATIFESENFFLPGIKWNGILGLAYAALAKPSSSLETFFDSLVAQAKIPDIFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARTSLIPEFSDGFWTGAQLACWTNSETPWAYFPKISIYLRDENASRSFRITILPQLYIQPMMGAGFNYECYRFGISSSTNALVIGATVMEGFYVVFDRAQRRVGFAVSPCAEIAGTTVSEISGPFSTEDIASNCVPAQALNEPILWIVSYALMSVCGAILLVLILLLLFPLHCRHAPRDPEVVNDESSLVRHRWK
  
Inhibitor
Name:
BDBM50428342
Synonyms:
CHEMBL2331710
Type:
Small organic molecule
Emp. Form.:
C18H17ClN4OS
Mol. Mass.:
372.872
SMILES:
NC1=NC2(CC2CCS1)c1cccc(NC(=O)c2ccc(Cl)cn2)c1 |t:1|
Structure:
Search PDB for entries with ligand similarity: