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Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50428883
Substrate
n/a
Meas. Tech.
ChEMBL_946081 (CHEMBL2342574)
IC50
18±n/a nM
Citation
 Taygerly, JP; McGee, LR; Rubenstein, SM; Houze, JB; Cushing, TD; Li, Y; Motani, A; Chen, JL; Frankmoelle, W; Ye, G; Learned, MR; Jaen, J; Miao, S; Timmermans, PB; Thoolen, M; Kearney, P; Flygare, J; Beckmann, H; Weiszmann, J; Lindstrom, M; Walker, N; Liu, J; Biermann, D; Wang, Z; Hagiwara, A; Iida, T; Aramaki, H; Kitao, Y; Shinkai, H; Furukawa, N; Nishiu, J; Nakamura, M Discovery of INT131: a selective PPAR¿ modulator that enhances insulin sensitivity. Bioorg Med Chem 21:979-92 (2013) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Homo sapiens (Human)
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM50428883
Synonyms:
CHEMBL2331774
Type:
Small organic molecule
Emp. Form.:
C21H16BrClF3N3O5S
Mol. Mass.:
594.786
SMILES:
CCNC(=O)c1cc(NS(=O)(=O)c2ccc(Br)cc2OC(F)(F)F)ccc1Oc1cncc(Cl)c1
Structure:
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