Reaction Details Report a problem with these data
Target
Translocator protein
Ligand
BDBM50421100
Substrate
n/a
Meas. Tech.
ChEMBL_945637 (CHEMBL2344971)
Ki
9.0±n/a nM
Citation
 Fukaya, T; Kodo, T; Ishiyama, T; Nishikawa, H; Baba, S; Masumoto, S Design, synthesis and structure-activity relationship of novel tricyclic benzimidazolone derivatives as potent 18 kDa translocator protein (TSPO) ligands. Bioorg Med Chem 21:1257-67 (2013) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50421100
Synonyms:
CHEMBL2088358
Type:
Small organic molecule
Emp. Form.:
C22H18N2O3
Mol. Mass.:
358.3899
SMILES:
CN(C(=O)Cn1c2cccc(-c3ccccc3)c2oc1=O)c1ccccc1
Structure:
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