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Target
Carbonic anhydrase 12
Ligand
BDBM50429909
Substrate
n/a
Meas. Tech.
ChEMBL_945278 (CHEMBL2340476)
pH
7±n/a
Kd
100±n/a nM
Comments
extracted
Citation
 Dudutiene, V; Zubriene, A; Smirnov, A; Gylyte, J; Timm, D; Manakova, E; Gražulis, S; Matulis, D 4-Substituted-2,3,5,6-tetrafluorobenzenesulfonamides as inhibitors of carbonic anhydrases I, II, VII, XII, and XIII. Bioorg Med Chem 21:2093-106 (2013) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 12
Synonyms:
CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:
Enzyme
Mol. Mass.:
39456.00
Organism:
Homo sapiens (Human)
Description:
Catalytic domain of human cloned isozyme was used in the assay
Residue:
354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
  
Inhibitor
Name:
BDBM50429909
Synonyms:
CHEMBL2333409
Type:
Small organic molecule
Emp. Form.:
C16H15F4NO2S2
Mol. Mass.:
393.419
SMILES:
Cc1cc(C)c(CSc2c(F)c(F)c(c(F)c2F)S(N)(=O)=O)c(C)c1
Structure:
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