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Target
Transmembrane protease serine 4
Ligand
BDBM50430191
Substrate
n/a
Meas. Tech.
ChEMBL_942945 (CHEMBL2343323)
IC50
19000±n/a nM
Citation
 Kang, S; Min, HJ; Kang, MS; Jung, MG; Kim, S Discovery of novel 2-hydroxydiarylamide derivatives as TMPRSS4 inhibitors. Bioorg Med Chem Lett 23:1748-51 (2013) [PubMed]  Article 
Target
Name:
Transmembrane protease serine 4
Synonyms:
CAPH2 | Channel-activating protease 2 | MT-SP2 | Membrane-type serine protease 2 | TMPRSS3 | TMPRSS4 | TMPS4_HUMAN
Type:
PROTEIN
Mol. Mass.:
48237.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_942945
Residue:
437
Sequence:
MLQDPDSDQPLNSLDVKPLRKPRIPMETFRKVGIPIIIALLSLASIIIVVVLIKVILDKYYFLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQELRMRNSSGPCLSGSLVSLHCLACGKSLKTPRVVGVEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWIYNVWKAEL
  
Inhibitor
Name:
BDBM50430191
Synonyms:
CHEMBL2338697
Type:
Small organic molecule
Emp. Form.:
C16H8F6N2O2
Mol. Mass.:
374.2373
SMILES:
Oc1ccc(cc1C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C#N
Structure:
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