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Target
D-amino-acid oxidase
Ligand
BDBM50431083
Substrate
n/a
Meas. Tech.
ChEMBL_947854 (CHEMBL2343130)
IC50
16±n/a nM
Citation
 Hondo, T; Warizaya, M; Niimi, T; Namatame, I; Yamaguchi, T; Nakanishi, K; Hamajima, T; Harada, K; Sakashita, H; Matsumoto, Y; Orita, M; Takeuchi, M 4-Hydroxypyridazin-3(2H)-one derivatives as novel D-amino acid oxidase inhibitors. J Med Chem 56:3582-92 (2013) [PubMed]  Article 
Target
Name:
D-amino-acid oxidase
Synonyms:
D-Amino Acid Oxidase (DAAO) | DAMOX | Dao | Dao1 | OXDA_RAT
Type:
Homodimer
Mol. Mass.:
38824.91
Organism:
Rattus norvegicus (rat)
Description:
Recombinant rat DAAO expressed and purified from sf9 insect cells, was used in enzyme assays.
Residue:
346
Sequence:
MRVAVIGAGVIGLSTALCIHERYHPAQPLHMKIYADRFTPFTTSDVAAGLWQPYLSDPSNPQEAEWNQQTFDHLQSCLHSPNAEKMGLALISGYNLFRDEVPDPFWKSTVLGFRKLTPSELDMFPDYSYGWFNTSLLLEGKSYLSWLTERLTERGVKFIHRKVASFEEVVRGGVDVIINCTGVWAGALQADASLQPGRGQIIQVEAPWIKHFILTHDPSLGIYNSPYIIPGSKTVTLGGVFQLGNWSELNSVHDHNTIWKSCCQLEPTLKNARIMGELTGFRPVRPQVRLERERLRFGSSSAEVIHNYGHGGYGLTIHWGCAMEAANLFGKILEEKNLSRMPPSHL
  
Inhibitor
Name:
BDBM50431083
Synonyms:
CHEMBL2338803 | US10202399, Example 24 | US10463663, Example 8 | US11129828, Example 8 | US9212147, 24 | US9290456, 8 | US9931340, Example 8
Type:
Small organic molecule
Emp. Form.:
C12H10F2N2O2
Mol. Mass.:
252.2168
SMILES:
Oc1cc(CCc2cc(F)cc(F)c2)n[nH]c1=O
Structure:
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