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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50179267
Substrate
n/a
Meas. Tech.
ChEMBL_950874 (CHEMBL2349698)
Ki
6.2±n/a nM
Citation
 Niso, M; Abate, C; Ferorelli, S; Cassano, G; Gasparre, G; Perrone, R; Berardi, F Investigation ofs receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines. Bioorg Med Chem 21:1865-9 (2013) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50179267
Synonyms:
1-(4-(6-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)butyl)-2,2-dimethylpiperidine hydrochloride | CHEMBL1189823 | CHEMBL539545
Type:
Small organic molecule
Emp. Form.:
C22H35NO
Mol. Mass.:
329.5194
SMILES:
COc1ccc2C(CCCCN3CCCCC3(C)C)CCCc2c1
Structure:
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