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Target
Arginase-2, mitochondrial
Ligand
BDBM50431956
Substrate
n/a
Meas. Tech.
ChEMBL_954165 (CHEMBL2351680)
IC50
4500±n/a nM
Citation
 Golebiowski, A; Paul Beckett, R; Van Zandt, M; Ji, MK; Whitehouse, D; Ryder, TR; Jagdmann, E; Andreoli, M; Mazur, A; Padmanilayam, M; Cousido-Siah, A; Mitschler, A; Ruiz, FX; Podjarny, A; Schroeter, H 2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors. Bioorg Med Chem Lett 23:2027-30 (2013) [PubMed]  Article 
Target
Name:
Arginase-2, mitochondrial
Synonyms:
ARG2 | ARGI2_HUMAN | Arginase II | Kidney-type arginase | Non-hepatic arginase | Type II arginase
Type:
PROTEIN
Mol. Mass.:
38576.93
Organism:
Homo sapiens (Human)
Description:
ChEMBL_978892
Residue:
354
Sequence:
MSLRGSLSRLLQTRVHSILKKSVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRI
  
Inhibitor
Name:
BDBM50431956
Synonyms:
CHEMBL2348495
Type:
Small organic molecule
Emp. Form.:
C9H20BNO5
Mol. Mass.:
233.07
SMILES:
NC(CCCO)(CCCCB(O)O)C(O)=O
Structure:
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