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Target
Urotensin-2 receptor
Ligand
BDBM50431962
Substrate
n/a
Meas. Tech.
ChEMBL_954175 (CHEMBL2351690)
IC50
6400±n/a nM
Citation
 Taylor, SJ; Soleymanzadeh, F; Muegge, I; Akiba, I; Taki, N; Ueda, S; Mainolfi, E; Eldrup, AB Deconstruction of sulfonamide inhibitors of the urotensin receptor (UT) and design and synthesis of benzylamine and benzylsulfone antagonists. Bioorg Med Chem Lett 23:2177-80 (2013) [PubMed]  Article 
Target
Name:
Urotensin-2 receptor
Synonyms:
G-protein coupled receptor 14 | Gpr14 | UR-2-R | UR-II-R | UR2R_MOUSE | Uts2r
Type:
PROTEIN
Mol. Mass.:
42543.59
Organism:
Mus musculus
Description:
ChEMBL_954175
Residue:
385
Sequence:
MALSLESTSFPMLAVSRSTASELPGGFNVSHNSSWTGPTDPSSLQDLVATGVIGAVLSTMGVVGVVGNVYTLVVMCRFLRASASMYVYVVNLALADLLYLLSIPFIVATYVTKDWHFGDVGCRVLFSLDFLTMHASIFTLTIMSSERYAAVLRPLDTVQRSKGYRKLLALGTWLLALLLTLPMMLAIRLVRRGSKSLCLPAWGPRAHRTYLTLLFGTSIVGPGLVIGLLYIRLARAYWLSQQASFKQTRRLPNPRVLYLILGIVLLFWACFLPFWLWQLLAQYHQAMPLTPETARIINYLTACLTYGNSCINPFLYTLLTKNYREYLRGRQRSLGSSCRGPGSAGSFLSSRVHLQQDSGRSLSSNSQQATETLVLSPVPPNGAFV
  
Inhibitor
Name:
BDBM50431962
Synonyms:
CHEMBL2348511
Type:
Small organic molecule
Emp. Form.:
C21H24BrF3N2O3
Mol. Mass.:
489.326
SMILES:
COc1cc(Br)c(CNc2ccc(c(O[C@H]3CCN(C)C3)c2)C(F)(F)F)cc1OC |r|
Structure:
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