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Target
CX3C chemokine receptor 1
Ligand
BDBM50432430
Substrate
n/a
Meas. Tech.
ChEMBL_953474 (CHEMBL2351085)
Ki
1200±n/a nM
Citation
 Karlström, S; Nordvall, G; Sohn, D; Hettman, A; Turek, D; Åhlin, K; Kers, A; Claesson, M; Slivo, C; Lo-Alfredsson, Y; Petersson, C; Bessidskaia, G; Svensson, PH; Rein, T; Jerning, E; Malmberg, Å; Ahlgen, C; Ray, C; Vares, L; Ivanov, V; Johansson, R Substituted 7-amino-5-thio-thiazolo[4,5-d]pyrimidines as potent and selective antagonists of the fractalkine receptor (CX3CR1). J Med Chem 56:3177-90 (2013) [PubMed]  Article 
Target
Name:
CX3C chemokine receptor 1
Synonyms:
C-X3-C chemokine receptor 1 | CMKBRL1 | CX3C1_HUMAN | CX3CR1 | GPR13
Type:
PROTEIN
Mol. Mass.:
40399.45
Organism:
Homo sapiens (Human)
Description:
ChEMBL_953474
Residue:
355
Sequence:
MDQFPESVTENFEYDDLAEACYIGDIVVFGTVFLSIFYSVIFAIGLVGNLLVVFALTNSKKPKSVTDIYLLNLALSDLLFVATLPFWTHYLINEKGLHNAMCKFTTAFFFIGFFGSIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVAAPQFMFTKQKENECLGDYPEVLQEIWPVLRNVETNFLGFLLPLLIMSYCYFRIIQTLFSCKNHKKAKAIKLILLVVIVFFLFWTPYNVMIFLETLKLYDFFPSCDMRKDLRLALSVTETVAFSHCCLNPLIYAFAGEKFRRYLYHLYGKCLAVLCGRSVHVDFSSSESQRSRHGSVLSSNFTYHTSDGDALLLL
  
Inhibitor
Name:
BDBM50432430
Synonyms:
CHEMBL2349331
Type:
Small organic molecule
Emp. Form.:
C19H22N6OS2
Mol. Mass.:
414.548
SMILES:
CC(C)C[C@H](CO)Nc1nc(SCc2ccc(cc2)C#N)nc2nc(N)sc12 |r|
Structure:
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