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Target
Vesicular acetylcholine transporter
Ligand
BDBM50432550
Substrate
n/a
Meas. Tech.
ChEMBL_950471 (CHEMBL2351223)
Ki
631±n/a nM
Citation
 Li, Y; Wang, X; Zhang, J; Deuther-Conrad, W; Xie, F; Zhang, X; Liu, J; Qiao, J; Cui, M; Steinbach, J; Brust, P; Liu, B; Jia, H Synthesis and evaluation of novel (18)F-labeled spirocyclic piperidine derivatives ass1 receptor ligands for positron emission tomography imaging. J Med Chem 56:3478-91 (2013) [PubMed]  Article 
Target
Name:
Vesicular acetylcholine transporter
Synonyms:
Slc18a3 | Solute carrier family 18 member 3 | VACHT_RAT | Vacht | Vat | rVAT
Type:
PROTEIN
Mol. Mass.:
56533.41
Organism:
Rattus norvegicus
Description:
ChEMBL_1503353
Residue:
530
Sequence:
MEPTAPTGQARAAATKLSEAVGAALQEPQRQRRLVLVIVCVALLLDNMLYMVIVPIVPDYIAHMRGGSEGPTLVSEVWEPTLPPPTLANASAYLANTSASPTAAGSARSILRPRYPTESEDVKIGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKYPEEPERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFSAAARARANLPVGTPIHRLMLDPYIAVVAGALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHLQWLYGALGLAVIGVSSCVVPACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRHVSVYGSVYAIADISYSVAYALGPIVAGHIVHSLGFEQLSLGMGLANLLYAPVLLLLRNVGLLTRSRSERDVLLDEPPQGLYDAVRLREVQGKDGGEPCSPPGPFDGCEDDYNYYSRS
  
Inhibitor
Name:
BDBM50432550
Synonyms:
CHEMBL2347001
Type:
Small organic molecule
Emp. Form.:
C21H24FNO2
Mol. Mass.:
341.4192
SMILES:
FCCOc1ccc(CN2CCC3(CC2)OCc2ccccc32)cc1
Structure:
Search PDB for entries with ligand similarity: