Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM50432644
Substrate
n/a
Meas. Tech.
ChEMBL_951640 (CHEMBL2351554)
IC50
15200±n/a nM
Citation
 Gonzalez-Lopez de Turiso, FSun, DRew, YBartberger, MDBeck, HPCanon, JChen, AChow, DCorrell, TLHuang, XJulian, LDKayser, FLo, MCLong, AMMcMinn, DOliner, JDOsgood, TPowers, JPSaiki, AYSchneider, SShaffer, PXiao, SHYakowec, PYan, XYe, QYu, DZhao, XZhou, JMedina, JCOlson, SH Rational design and binding mode duality of MDM2-p53 inhibitors. J Med Chem 56:4053-70 (2013) [PubMed]  Article 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM50432644
Synonyms:
CHEMBL2347391
Type:
Small organic molecule
Emp. Form.:
C23H23Cl2NO4
Mol. Mass.:
448.339
SMILES:
OC(=O)CC[C@@H]1O[C@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1 |r|
Structure:
Search PDB for entries with ligand similarity: