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TargetE3 ubiquitin-protein ligase Mdm2
LigandBDBM50432652
Substrate/Competitorn/a
Meas. Tech.ChEMBL_951641
IC50 610±n/a nM
Citation Gonzalez-Lopez de Turiso, FSun, DRew, YBartberger, MDBeck, HPCanon, JChen, AChow, DCorrell, TLHuang, XJulian, LDKayser, FLo, MCLong, AMMcMinn, DOliner, JDOsgood, TPowers, JPSaiki, AYSchneider, SShaffer, PXiao, SHYakowec, PYan, XYe, QYu, DZhao, XZhou, JMedina, JCOlson, SH Rational design and binding mode duality of MDM2-p53 inhibitors. J Med Chem56:4053-70 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
E3 ubiquitin-protein ligase Mdm2
Name:MDM2-MDMX
Synonyms:Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | p53-Binding Protein MDM2 | p53-binding protein
Type:Oncoprotein
Mol. Mass.:55196.54
Organism:Homo sapiens (Human)
Description:n/a
Residue:491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVP
DCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQ
DKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQ
PIQMIVLTYFP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50432652
NameBDBM50432652
Synonyms:CHEMBL2347393
TypeSmall organic molecule
Emp. Form.C22H23Cl2NO5
Mol. Mass.452.328
SMILESCC[C@@H](CO)N1[C@@H]([C@@H](O[C@@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a