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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM50432651
Substrate
n/a
Meas. Tech.
ChEMBL_951641 (CHEMBL2351555)
IC50
70±n/a nM
Citation
 Gonzalez-Lopez de Turiso, F; Sun, D; Rew, Y; Bartberger, MD; Beck, HP; Canon, J; Chen, A; Chow, D; Correll, TL; Huang, X; Julian, LD; Kayser, F; Lo, MC; Long, AM; McMinn, D; Oliner, JD; Osgood, T; Powers, JP; Saiki, AY; Schneider, S; Shaffer, P; Xiao, SH; Yakowec, P; Yan, X; Ye, Q; Yu, D; Zhao, X; Zhou, J; Medina, JC; Olson, SH Rational design and binding mode duality of MDM2-p53 inhibitors. J Med Chem 56:4053-70 (2013) [PubMed]  Article 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM50432651
Synonyms:
CHEMBL2347394
Type:
Small organic molecule
Emp. Form.:
C26H20Br2N4O2
Mol. Mass.:
580.271
SMILES:
COc1cccc2O[C@@H](C3=C(N(C)c4ncnn4[C@H]3c3ccc(Br)cc3)c12)c1ccc(Br)cc1 |r,t:9|
Structure:
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