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Target
Beta-1 adrenergic receptor
Ligand
BDBM25750
Substrate
n/a
Meas. Tech.
ChEMBL_952279 (CHEMBL2351585)
Kd
18±n/a nM
Citation
 Mistry, SN; Baker, JG; Fischer, PM; Hill, SJ; Gardiner, SM; Kellam, B Synthesis and in vitro and in vivo characterization of highlyß1-selectiveß-adrenoceptor partial agonists. J Med Chem 56:3852-65 (2013) [PubMed]  Article 
Target
Name:
Beta-1 adrenergic receptor
Synonyms:
ADRB1 | ADRB1R | ADRB1_HUMAN | B1AR | Beta-1 adrenoceptor | adrenergic Beta1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51338.40
Organism:
Homo sapiens (Human)
Description:
P08588
Residue:
477
Sequence:
MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
  
Inhibitor
Name:
BDBM25750
Synonyms:
N-(2-{[(2R)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino}ethyl)morpholine-4-carboxamide | Xamoterol
Type:
Small organic molecule
Emp. Form.:
C16H25N3O5
Mol. Mass.:
339.3868
SMILES:
O[C@H](CNCCNC(=O)N1CCOCC1)COc1ccc(O)cc1
Structure:
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