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Target
Inosine-5'-monophosphate dehydrogenase
Ligand
BDBM50432801
Substrate
n/a
Meas. Tech.
ChEMBL_953212 (CHEMBL2354115)
IC50
19±n/a nM
Citation
 Gorla, SK; Kavitha, M; Zhang, M; Chin, JE; Liu, X; Striepen, B; Makowska-Grzyska, M; Kim, Y; Joachimiak, A; Hedstrom, L; Cuny, GD Optimization of benzoxazole-based inhibitors of Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase. J Med Chem 56:4028-43 (2013) [PubMed]  Article 
Target
Name:
Inosine-5'-monophosphate dehydrogenase
Synonyms:
Cgd6_20 protein | IMDH_CRYPV | Inosine-5'-monophosphate dehydrogenase, probable | Inosine-5-monophosphate dehydrogenase (IMPDH)
Type:
Protein
Mol. Mass.:
43076.80
Organism:
Cryptosporidium parvum
Description:
Q8T6T2
Residue:
400
Sequence:
MGTKNIGKGLTFEDILLVPNYSEVLPREVSLETKLTKNVSLKIPLISSAMDTVTEHLMAVGMARLGGIGIIHKNMDMESQVNEVLKVKNWISNLEKNESTPDQNLDKESTDGKDTKSNNNIDAYSNENLDNKGRLRVGAAIGVNEIERAKLLVEAGVDVIVLDSAHGHSLNIIRTLKEIKSKMNIDVIVGNVVTEEATKELIENGADGIKVGIGPGSICTTRIVAGVGVPQITAIEKCSSVASKFGIPIIADGGIRYSGDIGKALAVGASSVMIGSILAGTEESPGEKELIGDTVYKYYRGMGSVGAMKSGSGDRYFQEKRPENKMVPEGIEGRVKYKGEMEGVVYQLVGGLRSCMGYLGSASIEELWKKSSYVEITTSGLRESHVHDVEIVKEVMNYSK
  
Inhibitor
Name:
BDBM50432801
Synonyms:
CHEMBL2348811
Type:
Small organic molecule
Emp. Form.:
C21H16ClN3O3
Mol. Mass.:
393.823
SMILES:
CC(Oc1ccccc1Cl)C(=O)Nc1ccc2oc(nc2c1)-c1ccncc1
Structure:
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