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Target
Mitogen-activated protein kinase 10
Ligand
BDBM50433093
Substrate
n/a
Meas. Tech.
ChEMBL_956396 (CHEMBL2379709)
IC50
5300±n/a nM
Citation
 Jiang, R; Frackowiak, B; Shin, Y; Song, X; Chen, W; Lin, L; Cameron, MD; Duckett, DR; Kamenecka, TM Design and synthesis of 1-aryl-5-anilinoindazoles as c-Jun N-terminal kinase inhibitors. Bioorg Med Chem Lett 23:2683-7 (2013) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 10
Synonyms:
Jnk3 | MK10_RAT | Mapk10 | Prkm10 | c-Jun N-terminal kinase 3
Type:
PROTEIN
Mol. Mass.:
52534.34
Organism:
Rattus norvegicus
Description:
ChEMBL_1460661
Residue:
464
Sequence:
MSLHFLYYCSEPTLDVKIAFCQGFDKHVDVSSVVKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
  
Inhibitor
Name:
BDBM50433093
Synonyms:
CHEMBL2376930
Type:
Small organic molecule
Emp. Form.:
C25H25ClN6O2
Mol. Mass.:
476.958
SMILES:
Clc1ccccc1Nc1ccc2n(ncc2c1)-c1cc(ccn1)C(=O)NCCN1CCOCC1
Structure:
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