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Target
Long-chain fatty acid transport protein 1
Ligand
BDBM50433153
Substrate
n/a
Meas. Tech.
ChEMBL_956919 (CHEMBL2378195)
IC50
5400±n/a nM
Citation
 Matsufuji, T; Ikeda, M; Naito, A; Hirouchi, M; Kanda, S; Izumi, M; Harada, J; Shinozuka, T Arylpiperazines as fatty acid transport protein 1 (FATP1) inhibitors with improved potency and pharmacokinetic properties. Bioorg Med Chem Lett 23:2560-5 (2013) [PubMed]  Article 
Target
Name:
Long-chain fatty acid transport protein 1
Synonyms:
6.2.1.- | FATP-1 | Fatp | Fatp1 | Fatty acid transport protein 1 | S27A1_MOUSE | Slc27a1 | Solute carrier family 27 member 1
Type:
PROTEIN
Mol. Mass.:
71289.41
Organism:
Mus musculus
Description:
ChEMBL_956919
Residue:
646
Sequence:
MRAPGAGTASVASLALLWFLGLPWTWSAAAAFCVYVGGGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRHRRAGDTIPCIFQAVARRQPERLALVDASSGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIYGGEMAAAVAEVSEQLGKSLLKFCSGDLGPESILPDTQLLDPMLAEAPTTPLAQAPGKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLTVVLRKKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPVRDVEQRHRVRLAVGNGLRPAIWEEFTQRFGVPQIGEFYGATECNCSIANMDGKVGSCGFNSRILTHVYPIRLVKVNEDTMEPLRDSEGLCIPCQPGEPGLLVGQINQQDPLRRFDGYVSDSATNKKIAHSVFRKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPGVEGKAGMAAIADPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRLQREGFDPRQTSDRLFFLDLKQGRYVPLDERVHARICAGDFSL
  
Inhibitor
Name:
BDBM50433153
Synonyms:
CHEMBL2377764
Type:
Small organic molecule
Emp. Form.:
C19H23FN4O2
Mol. Mass.:
358.4099
SMILES:
Fc1ccc(cc1)N1CCN(CC(=O)Nc2nc3CCCCc3o2)CC1
Structure:
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