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Target
Tyrosine-protein phosphatase non-receptor type 2
Ligand
BDBM50433176
Substrate
n/a
Meas. Tech.
ChEMBL_956929 (CHEMBL2378246)
Ki
136500±n/a nM
Citation
 Chandrasekharappa, AP; Badiger, SE; Dubey, PK; Panigrahi, SK; Manukonda, SR Design and synthesis of 2-substituted benzoxazoles as novel PTP1B inhibitors. Bioorg Med Chem Lett 23:2579-84 (2013) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 2
Synonyms:
PTN2_HUMAN | PTPN2 | PTPT | T-cell protein tyrosine phosphatase (TCPTP) | T-cell protein-tyrosine phosphatase | TC-PTP | TCPTP | Tyrosine-protein phosphatase non-receptor type 2 | Tyrosine-protein phosphatase non-receptor type 2 (TC-PTP)
Type:
Protein
Mol. Mass.:
48481.80
Organism:
Homo sapiens (Human)
Description:
P17706
Residue:
415
Sequence:
MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPAFDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKATTAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
  
Inhibitor
Name:
BDBM50433176
Synonyms:
CHEMBL2375439
Type:
Small organic molecule
Emp. Form.:
C17H15N3O6S
Mol. Mass.:
389.383
SMILES:
NS(=O)(=O)C(Cc1ccc(NC(=O)C(O)=O)cc1)c1nc2ccccc2o1
Structure:
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