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Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50433163
Substrate
n/a
Meas. Tech.
ChEMBL_956926 (CHEMBL2378243)
Ki
92000±n/a nM
Citation
 Chandrasekharappa, AP; Badiger, SE; Dubey, PK; Panigrahi, SK; Manukonda, SR Design and synthesis of 2-substituted benzoxazoles as novel PTP1B inhibitors. Bioorg Med Chem Lett 23:2579-84 (2013) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50433163
Synonyms:
CHEMBL2377804
Type:
Small organic molecule
Emp. Form.:
C26H25N3O7S
Mol. Mass.:
523.558
SMILES:
CC(C)Oc1ccc(NS(=O)(=O)C(Cc2ccc(NC(=O)C(O)=O)cc2)c2nc3ccccc3o2)cc1
Structure:
Search PDB for entries with ligand similarity: