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Target
Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
Ligand
BDBM50433269
Substrate
n/a
Meas. Tech.
ChEMBL_957854 (CHEMBL2378967)
IC50
50±n/a nM
Citation
 Barlind, JG; Buckett, LK; Crosby, SG; Davidsson, Ö; Emtenäs, H; Ertan, A; Jurva, U; Lemurell, M; Gutierrez, PM; Nilsson, K; O'Mahony, G; Petersson, AU; Redzic, A; Wågberg, F; Yuan, ZQ Identification and design of a novel series of MGAT2 inhibitors. Bioorg Med Chem Lett 23:2721-6 (2013) [PubMed]  Article 
Target
Name:
Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
Synonyms:
GGNT3 | GNT-III | GlcNAc-T III | MGAT3 | MGAT3_HUMAN | N-acetylglucosaminyltransferase III | N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III
Type:
PROTEIN
Mol. Mass.:
61324.81
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107586
Residue:
533
Sequence:
MKMRRYKLFLMFCMAGLCLISFLHFFKTLSYVTFPRELASLSPNLVSSFFWNNAPVTPQASPEPGGPDLLRTPLYSHSPLLQPLPPSKAAEELHRVDLVLPEDTTEYFVRTKAGGVCFKPGTKMLERPPPGRPEEKPEGANGSSARRPPRYLLSARERTGGRGARRKWVECVCLPGWHGPSCGVPTVVQYSNLPTKERLVPREVPRRVINAINVNHEFDLLDVRFHELGDVVDAFVVCESNFTAYGEPRPLKFREMLTNGTFEYIRHKVLYVFLDHFPPGGRQDGWIADDYLRTFLTQDGVSRLRNLRPDDVFIIDDADEIPARDGVLFLKLYDGWTEPFAFHMRKSLYGFFWKQPGTLEVVSGCTVDMLQAVYGLDGIRLRRRQYYTMPNFRQYENRTGHILVQWSLGSPLHFAGWHCSWCFTPEGIYFKLVSAQNGDFPRWGDYEDKRDLNYIRGLIRTGGWFDGTQQEYPPADPSEHMYAPKYLLKNYDRFHYLLDNPYQEPRSTAAGGWRHRGPEGRPPARGKLDEAEV
  
Inhibitor
Name:
BDBM50433269
Synonyms:
CHEMBL2376303
Type:
Small organic molecule
Emp. Form.:
C18H17F2N3O4S
Mol. Mass.:
409.407
SMILES:
CC[C@]1(C)NC(=O)c2cc(ccc2NC1=O)S(=O)(=O)Nc1ccc(F)cc1F |r|
Structure:
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