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Target
D-amino-acid oxidase
Ligand
BDBM50260722
Substrate
n/a
Meas. Tech.
ChEMBL_956978 (CHEMBL2378326)
Kd
2500±n/a nM
Citation
 Hopkins, SC; Heffernan, ML; Saraswat, LD; Bowen, CA; Melnick, L; Hardy, LW; Orsini, MA; Allen, MS; Koch, P; Spear, KL; Foglesong, RJ; Soukri, M; Chytil, M; Fang, QK; Jones, SW; Varney, MA; Panatier, A; Oliet, SH; Pollegioni, L; Piubelli, L; Molla, G; Nardini, M; Large, TH Structural, kinetic, and pharmacodynamic mechanisms of D-amino acid oxidase inhibition by small molecules. J Med Chem 56:3710-24 (2013) [PubMed]  Article 
Target
Name:
D-amino-acid oxidase
Synonyms:
D-amino-acid oxidase (DAAO) | DAAO | DAMOX | DAO | OXDA_HUMAN
Type:
Homodimer
Mol. Mass.:
39476.06
Organism:
Homo sapiens (Human)
Description:
P14920
Residue:
347
Sequence:
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLSRMPPSHL
  
Inhibitor
Name:
BDBM50260722
Synonyms:
4-(4-chlorophenethyl)-1H-pyrrole-2-carboxylic acid | CHEMBL453239
Type:
Small organic molecule
Emp. Form.:
C13H12ClNO2
Mol. Mass.:
249.693
SMILES:
OC(=O)c1cc(CCc2ccc(Cl)cc2)c[nH]1
Structure:
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