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Target
Transcriptional activator Myb
Ligand
BDBM50433467
Substrate
n/a
Meas. Tech.
ChEMBL_958516 (CHEMBL2383288)
IC50
16630±n/a nM
Citation
 Schomburg, C; Schuehly, W; Da Costa, FB; Klempnauer, KH; Schmidt, TJ Natural sesquiterpene lactones as inhibitors of Myb-dependent gene expression: structure-activity relationships. Eur J Med Chem 63:313-20 (2013) [PubMed]  Article 
Target
Name:
Transcriptional activator Myb
Synonyms:
MYB | MYB_CHICK | Proto-oncogene c-Myb
Type:
PROTEIN
Mol. Mass.:
72474.34
Organism:
Gallus gallus
Description:
ChEMBL_107588
Residue:
641
Sequence:
MARRPRHSIYSSDDDEEDVEMYDHDYDGLLPKAGKRHLGKTRWTREEDEKLKKLVEQNGTEDWKVIASFLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSVIAKHLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNAIKNHWNSTMRRKVEQEGYLQESSKAGLPSATTGFQKSSHLMAFAHNPPAGPLPGAGQAPLGSDYPYYHIAEPQNVPGQIPYPVALHVNIVNVPQPAAAAIQRHYNDEDPEKEKRIKELELLLMSTENELKGQQALPTQNHTANYPGWHSTTVADNTRTSGDNAPVSCLGEHHHCTPSPPVDHGCLPEESASPARCMIVHQSNILDNVKNLLEFAETLQLIDSFLNTSSNHENLNLDNPALTSTPVCGHKMSVTTPFHRDQPFKTQKENHVFRTPAIKRSILESSPRTPTPFKNALAAQEIKYGPLKMLPQTPTHLVEDLQDVIKQESEESAIVAGLHESGPPLLKKIKQEVESPTDKAGNFFCSNHWEGENLNTQLFTHASTMEDVPNLLTSSILKMPVSEEEGSFHKAFAVPRNRPLASPMQHLNNAWESASCGKTEDQMALTDQARKYMAAFPTRTLVM
  
Inhibitor
Name:
BDBM50433467
Synonyms:
6-O-Isovaleryldihydrohelenalin | CHEMBL452752
Type:
Small organic molecule
Emp. Form.:
C20H28O5
Mol. Mass.:
348.4333
SMILES:
CC(C)CC(=O)O[C@H]1[C@H]2[C@@H](C[C@@H](C)[C@@H]3C=CC(=O)[C@@]13C)OC(=O)[C@H]2C |r,c:14|
Structure:
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