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Target
Glucagon-like peptide 1 receptor
Ligand
BDBM50433577
Substrate
n/a
Meas. Tech.
ChEMBL_960234 (CHEMBL2382727)
Ki
3160±n/a nM
Citation
 Guzman-Perez, A; Pfefferkorn, JA; Lee, EC; Stevens, BD; Aspnes, GE; Bian, J; Didiuk, MT; Filipski, KJ; Moore, D; Perreault, C; Sammons, MF; Tu, M; Brown, J; Atkinson, K; Litchfield, J; Tan, B; Samas, B; Zavadoski, WJ; Salatto, CT; Treadway, J The design and synthesis of a potent glucagon receptor antagonist with favorable physicochemical and pharmacokinetic properties as a candidate for the treatment of type 2 diabetes mellitus. Bioorg Med Chem Lett 23:3051-8 (2013) [PubMed]  Article 
Target
Name:
Glucagon-like peptide 1 receptor
Synonyms:
GLP-1 receptor | GLP-1-R | GLP-1R | GLP1R | GLP1R_HUMAN | Glucagon-like peptide 1 receptor | Glucagon-like peptide 1 receptor (GLP-1)
Type:
Enzyme
Mol. Mass.:
53035.78
Organism:
Homo sapiens (Human)
Description:
P43220
Residue:
463
Sequence:
MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
  
Inhibitor
Name:
BDBM50433577
Synonyms:
CHEMBL2381848
Type:
Small organic molecule
Emp. Form.:
C26H28F3N3O4
Mol. Mass.:
503.5134
SMILES:
CCC[C@H](Oc1cc(C)c(c(C)c1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O |r|
Structure:
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