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Target
Chymase
Ligand
BDBM50434108
Substrate
n/a
Meas. Tech.
ChEMBL_958460 (CHEMBL2383101)
IC50
60±n/a nM
Citation
 Taylor, SJ; Padyana, AK; Abeywardane, A; Liang, S; Hao, MH; De Lombaert, S; Proudfoot, J; Farmer, BS; Li, X; Collins, B; Martin, L; Albaugh, DR; Hill-Drzewi, M; Pullen, SS; Takahashi, H Discovery of potent, selective chymase inhibitors via fragment linking strategies. J Med Chem 56:4465-81 (2013) [PubMed]  Article 
Target
Name:
Chymase
Synonyms:
Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I
Type:
Enzyme
Mol. Mass.:
27340.12
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN
  
Inhibitor
Name:
BDBM50434108
Synonyms:
CHEMBL2381482
Type:
Small organic molecule
Emp. Form.:
C22H22BrN3O4
Mol. Mass.:
472.332
SMILES:
CCCC(Cn1c2ccccc2n(Cc2cc(Br)cc3NC(=O)Cc23)c1=O)C(O)=O
Structure:
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