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Target
Cathepsin G
Ligand
BDBM50434111
Substrate
n/a
Meas. Tech.
ChEMBL_958459 (CHEMBL2383100)
IC50
>10000±n/a nM
Citation
 Taylor, SJ; Padyana, AK; Abeywardane, A; Liang, S; Hao, MH; De Lombaert, S; Proudfoot, J; Farmer, BS; Li, X; Collins, B; Martin, L; Albaugh, DR; Hill-Drzewi, M; Pullen, SS; Takahashi, H Discovery of potent, selective chymase inhibitors via fragment linking strategies. J Med Chem 56:4465-81 (2013) [PubMed]  Article 
Target
Name:
Cathepsin G
Synonyms:
CATG_HUMAN | CG | CTSG
Type:
PROTEIN
Mol. Mass.:
28860.08
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469016
Residue:
255
Sequence:
MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRRNRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIFGSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLPWIRTTMRSFKLLDQMETPL
  
Inhibitor
Name:
BDBM50434111
Synonyms:
CHEMBL2381485
Type:
Small organic molecule
Emp. Form.:
C19H16BrN3O4
Mol. Mass.:
430.252
SMILES:
OC(=O)CCn1c2ccccc2n(Cc2cc(Br)cc3NC(=O)Cc23)c1=O
Structure:
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