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Target
Protein mono-ADP-ribosyltransferase PARP3 [R100H]
Ligand
BDBM50434127
Substrate
n/a
Meas. Tech.
ChEMBL_958907 (CHEMBL2382485)
IC50
>10000±n/a nM
Citation
 Larsson, EA; Jansson, A; Ng, FM; Then, SW; Panicker, R; Liu, B; Sangthongpitag, K; Pendharkar, V; Tai, SJ; Hill, J; Dan, C; Ho, SY; Cheong, WW; Poulsen, A; Blanchard, S; Lin, GR; Alam, J; Keller, TH; Nordlund, P Fragment-based ligand design of novel potent inhibitors of tankyrases. J Med Chem 56:4497-508 (2013) [PubMed]  Article 
Target
Name:
Protein mono-ADP-ribosyltransferase PARP3 [R100H]
Synonyms:
(ARTD3 or PARP3) | ADP-ribosyltransferase diphtheria toxin-like 3 | ADPRT3 | ADPRTL3 | Human diphtheria toxin-like ADP-ribosyltransferase (ARTD3 or PARP3) | PARP3 | PARP3_HUMAN | Poly [ADP-ribose] polymerase 3 | Poly [ADP-ribose] polymerase 3 (PARP-3) | Poly(ADP-ribose) polymerase-3 (ARTD3/PARP3)
Type:
PROTEIN
Mol. Mass.:
60071.85
Organism:
Homo sapiens (Human)
Description:
Q9Y6F1[R100H]
Residue:
533
Sequence:
MAPKPKPWVQTEGPEKKKGRQAGREEDPFRSTAEALKAIPAEKRIIRVDPTCPLSSNPGTQVYEDYNCTLNQTNIENNNNKFYIIQLLQDSNRFFTCWNHWGRVGEVGQSKINHFTRLEDAKKDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQAEDEAQEAVVKVDRGPVRTVTKRVQPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEALKGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIELAQALQAVSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQTGSNHRCPTLQHIWKVNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGIYFASENSKSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHTEPDPTQDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEVHL
  
Inhibitor
Name:
BDBM50434127
Synonyms:
CHEMBL2381633
Type:
Small organic molecule
Emp. Form.:
C16H12FNO
Mol. Mass.:
253.271
SMILES:
Cc1cc(=O)[nH]c2cc(ccc12)-c1ccccc1F
Structure:
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