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Target
Sialidase-4
Ligand
BDBM50331679
Substrate
n/a
Meas. Tech.
ChEMBL_960637 (CHEMBL2390090)
IC50
810±n/a nM
Citation
 Albohy, A; Zhang, Y; Smutova, V; Pshezhetsky, AV; Cairo, CW Identification of Selective Nanomolar Inhibitors of the Human Neuraminidase, NEU4. ACS Med Chem Lett 4:532-7 (2013) [PubMed]  Article 
Target
Name:
Sialidase-4
Synonyms:
NEU4 | NEUR4_HUMAN | Sialidase 4
Type:
PROTEIN
Mol. Mass.:
51579.82
Organism:
Homo sapiens (Human)
Description:
ChEMBL_960637
Residue:
484
Sequence:
MGVPRTPSRTVLFERERTGLTYRVPSLLPVPPGPTLLAFVEQRLSPDDSHAHRLVLRRGTLAGGSVRWGALHVLGTAALAEHRSMNPCPVHDAGTGTVFLFFIAVLGHTPEAVQIATGRNAARLCCVASRDAGLSWGSARDLTEEAIGGAVQDWATFAVGPGHGVQLPSGRLLVPAYTYRVDRRECFGKICRTSPHSFAFYSDDHGRTWRCGGLVPNLRSGECQLAAVDGGQAGSFLYCNARSPLGSRVQALSTDEGTSFLPAERVASLPETAWGCQGSIVGFPAPAPNRPRDDSWSVGPGSPLQPPLLGPGVHEPPEEAAVDPRGGQVPGGPFSRLQPRGDGPRQPGPRPGVSGDVGSWTLALPMPFAAPPQSPTWLLYSHPVGRRARLHMGIRLSQSPLDPRSWTEPWVIYEGPSGYSDLASIGPAPEGGLVFACLYESGARTSYDEISFCTFSLREVLENVPASPKPPNLGDKPRGCCWPS
  
Inhibitor
Name:
BDBM50331679
Synonyms:
(2R,3R,4S)-3-acetamido-2-((1R,2R)-1,2-dihydroxy-3-(4-(2-hydroxyethyl)-1H-1,2,3-triazol-1-yl)propyl)-4-hydroxy-3,4-dihydro-2H-pyran-6-carboxylate | CHEMBL1289754
Type:
Small organic molecule
Emp. Form.:
C15H22N4O8
Mol. Mass.:
386.3572
SMILES:
CC(=O)N[C@@H]1[C@@H](O)C=C(O[C@H]1[C@H](O)[C@H](O)Cn1cc(CCO)nn1)C(O)=O |r,c:7|
Structure:
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