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Target
Histone deacetylase 3
Ligand
BDBM50434533
Substrate
n/a
Meas. Tech.
ChEMBL_961862 (CHEMBL2390154)
IC50
1360±n/a nM
Citation
 Zhang, X; Zhang, J; Tong, L; Luo, Y; Su, M; Zang, Y; Li, J; Lu, W; Chen, Y The discovery of colchicine-SAHA hybrids as a new class of antitumor agents. Bioorg Med Chem 21:3240-4 (2013) [PubMed]  Article 
Target
Name:
Histone deacetylase 3
Synonyms:
HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45
Type:
Enzyme
Mol. Mass.:
48829.55
Organism:
Homo sapiens (Human)
Description:
O15379
Residue:
428
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI
  
Inhibitor
Name:
BDBM50434533
Synonyms:
CHEMBL2385957
Type:
Small organic molecule
Emp. Form.:
C24H28N2O8
Mol. Mass.:
472.4877
SMILES:
COc1cc2CC[C@H](NC(=O)CCC(=O)NO)c3cc(=O)c(OC)ccc3-c2c(OC)c1OC |r|
Structure:
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