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Target
Serine/threonine-protein kinase pim-2
Ligand
BDBM50434654
Substrate
n/a
Meas. Tech.
ChEMBL_960800 (CHEMBL2387969)
Ki
0.037000±n/a nM
Citation
 Wang, X; Magnuson, S; Pastor, R; Fan, E; Hu, H; Tsui, V; Deng, W; Murray, J; Steffek, M; Wallweber, H; Moffat, J; Drummond, J; Chan, G; Harstad, E; Ebens, AJ Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design. Bioorg Med Chem Lett 23:3149-53 (2013) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-2
Synonyms:
PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2)
Type:
Serine/threonine-protein kinase
Mol. Mass.:
34185.93
Organism:
Homo sapiens (Human)
Description:
Q9P1W9
Residue:
311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP
  
Inhibitor
Name:
BDBM50434654
Synonyms:
CHEMBL2387465
Type:
Small organic molecule
Emp. Form.:
C26H23F3N8O
Mol. Mass.:
520.509
SMILES:
F[C@H]1CNCC[C@@H]1CNc1ccn2ncc(C(=O)Nc3c[nH]c4ncc(cc34)-c3c(F)cccc3F)c2n1 |r|
Structure:
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