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TargetNicotinamide phosphoribosyltransferase
LigandBDBM50347433
Substrate/Competitorn/a
Meas. Tech.ChEMBL_965360
IC50 0.500000±n/a nM
Citation Zheng, XBauer, PBaumeister, TBuckmelter, AJCaligiuri, MClodfelter, KHHan, BHo, YCKley, NLin, JReynolds, DJSharma, GSmith, CCWang, ZDragovich, PSOh, AWang, WZak, MGunzner-Toste, JZhao, GYuen, PWBair, KW Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (Nampt) inhibitors. J Med Chem56:4921-37 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Nicotinamide phosphoribosyltransferase
Name:Nicotinamide phosphoribosyltransferase
Synonyms:NAmPRTase | Nicotinamide phosphoribosyltransferase (NAMPT) | Pre-B-cell colony-enhancing factor 1
Type:Enzyme
Mol. Mass.:55524.98
Organism:Homo sapiens (Human)
Description:P43490
Residue:491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVP
EGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNA
QLNIELEAAHH
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  Blast E-value cutoff:
BDBM50347433
NameBDBM50347433
Synonyms:CHEMBL1801864
TypeSmall organic molecule
Emp. Form.C27H27ClN6O2
Mol. Mass.502.995
SMILES[#6]\[#6](-[#6])=[#6]\[#6]-[#7](-[#6]-c1cc2c(cc1Cl)nnn(-[#6])c2=O)-c1ccc(cc1)-[#6](=O)-[#7]-[#6]-c1cccnc1
Structure
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