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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50174298
Substrate
n/a
Meas. Tech.
ChEMBL_965016 (CHEMBL2396178)
IC50
3.0±n/a nM
Citation
 Bauman, DR; Whitehead, A; Contino, LC; Cui, J; Garcia-Calvo, M; Gu, X; Kevin, N; Ma, X; Pai, LY; Shah, K; Shen, X; Stribling, S; Zokian, HJ; Metzger, J; Shevell, DE; Waddell, ST Evaluation of selective inhibitors of 11ß-HSD1 for the treatment of hypertension. Bioorg Med Chem Lett 23:3650-3 (2013) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_RAT | Hsd11 | Hsd11b1
Type:
Enzyme
Mol. Mass.:
31889.48
Organism:
Rattus norvegicus (rat)
Description:
P16232
Residue:
288
Sequence:
MKKYLLPVLVLCLGYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMAFAERFVVEAGKLLGGLDMLILNHITQTTMSLFHDDIHSVRRSMEVNFLSYVVLSTAALPMLKQSNGSIAIISSMAGKMTQPLIASYSASKFALDGFFSTIRKEHLMTKVNVSITLCVLGFIDTETALKETSGIILSQAAPKEECALEIIKGTVLRKDEVYYDKSSWTPLLLGNPGRRIMEFLSLRSYNRDLFVSN
  
Inhibitor
Name:
BDBM50174298
Synonyms:
3-(4-(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole | CHEMBL373257
Type:
Small organic molecule
Emp. Form.:
C26H23F4N5O
Mol. Mass.:
497.4873
SMILES:
Cn1c(nnc1C12CCC(CC1)(CC2)c1nc(no1)-c1ccc(F)cc1)-c1ccccc1C(F)(F)F
Structure:
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